Duel of Meloch combines two existing games, Scythe and Expeditions. One player uses the Scythe rules and components (including a new faction and player mat found here); the other player uses the Expedition rules (including a new mech, character, and companion found here). The duel takes place in a tight space on a new double-sided map—only 10 locations and 2 lakes—so every turn is crucial.

All existing Scythe factions and player mats (along with most encounter cards) plus all existing Expeditions mechs, characters, and companions (along with most discovery cards) are compatible with Duel of Meloch. Likewise, the components in Duel of Meloch are compatible with Scythe and Expeditions.